1. Signaling Pathways
  2. Neuronal Signaling
  3. Cholinesterase (ChE)

Cholinesterase (ChE)

(ChE)

Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.

There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-Y0320
    Dimethyl sulfoxide, meets analytical specification of Ch.P.
    Inhibitor 99.99%
    Dimethyl sulfoxide (DMSO), meets analytical specification of Ch.P. is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties.
    MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition). Amicrobic, low endotoxin, can be used in various biochemical experiments such as drug dissolution.
    Dimethyl sulfoxide, meets analytical specification of Ch.P.
  • HY-Y0320C
    Dimethyl sulfoxide
    Inhibitor 99.98%
    Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity.
    Low endotoxin, can be used in various biochemical experiments such as drug dissolution.
    Dimethyl sulfoxide
  • HY-B0034
    Donepezil Hydrochloride
    Inhibitor 99.92%
    Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity.
    Donepezil Hydrochloride
  • HY-14566
    Donepezil
    Inhibitor 99.87%
    Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively.
    Donepezil
  • HY-108477
    TMPyP4 tosylate
    Inhibitor ≥98.0%
    TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2.
    TMPyP4 tosylate
  • HY-W009431
    AChE-IN-84
    Inhibitor
    AChE-IN-84 (compound 21) is an AChE inhibitor.
    AChE-IN-84
  • HY-W130025
    p-Xylene bis(pyridinium bromide)
    Inhibitor 99.60%
    p-Xylene bis(pyridinium bromide) (compound 21), a cationic charged quencher, is a week bisquaternary AChE and BChE inhibitor with IC50s of 1540 μM and 529 μM, respectively.
    p-Xylene bis(pyridinium bromide)
  • HY-N0285
    Imperatorin
    Inhibitor 98.72%
    Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM.
    Imperatorin
  • HY-101981
    Uridine 5'-monophosphate
    Activator 99.98%
    Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
    Uridine 5'-monophosphate
  • HY-17368
    Rivastigmine
    Inhibitor 99.93%
    Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
    Rivastigmine
  • HY-76299
    Galanthamine
    Inhibitor 99.96%
    Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.
    Galanthamine
  • HY-17552
    sn-Glycero-3-phosphocholine
    Activator ≥98.0%
    sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. sn-Glycero-3-phosphocholine (Choline Alfoscerate) has significant effects on cognitive function with a good safety profile and tolerability, and is effective in the treatment of Alzheimer's disease and dementia.
    sn-Glycero-3-phosphocholine
  • HY-107569
    Garcinol
    Inhibitor ≥99.0%
    Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity.
    Garcinol
  • HY-138097
    α-NETA
    Inhibitor ≥98.0%
    α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC50 of 9 μM. α-NETA is a potent ALDH1A1 (IC50=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC50=84 µM) and acetylcholinesterase (AChE; IC50=300 µM). α-NETA has anti-cancer activity.
    α-NETA
  • HY-P2860
    Acetylcholinesterase, Fly head
    Acetylcholinesterase, Fly head (ACHE; EC 3.1.1.7) is a cholinergic enzyme mainly found in neuromuscular junctions and cholinergic type chemical synapses used in biochemical research. Acetylcholinesterase, Fly head catalyzes the breakdown or hydrolysis of acetylcholine and some other choline esters that act as neurotransmitters into acetate and choline. Acetylcholinesterase, Fly head's main role is to terminate neuronal transmission and signaling between synapses to prevent ACh spread and activation of nearby receptors.
    Acetylcholinesterase, Fly head
  • HY-N0342
    Scopoletin
    Inhibitor 99.89%
    Scopoletin is an inhibitor of acetylcholinesterase (AChE).
    Scopoletin
  • HY-N0528
    Linarin
    Inhibitor 98.00%
    Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). Linarin has many activities, such as anti-inflammatory, antioxidant, sleep aid and sedation, bone differentiation, anti-tumor, antibacterial and antiviral. Linarin can be used to study diseases such as the nervous system, osteoporosis and cancer.
    Linarin
  • HY-B1266
    Physostigmine salicylate
    Inhibitor 99.74%
    Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning.
    Physostigmine salicylate
  • HY-B2152
    Hemicholinium 3
    Inhibitor 99.71%
    Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a Ki value of 25 nM. Hemicholinium 3, a neuromuscular blocking agent which inhibits the synthesis and the release of acetylcholine (ACh). Hemicholinium 3 inhibits the Epibatidine-evoked contraction and [3H]acetylcholine release with IC50s of 897 nM and 693 nM, respectively.
    Hemicholinium 3
  • HY-11017
    Rivastigmine tartrate
    Inhibitor 99.03%
    Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
    Rivastigmine tartrate
Cat. No. Product Name / Synonyms Application Reactivity

AChE

BChE

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Cholinesterase (ChE) Inhibitors, Agonists, Antagonists, Activators & Chemicals
Product NameAChEBChEPurity    
Donepezil Hydrochloride
AChE
 99.92%
Donepezil
AChE
 99.87%
TMPyP4 tosylate
AChE
 ≥98.0%
p-Xylene bis(pyridinium bromide)
hAChE, IC50: 1540 μM
BChE, IC50: 529 μM
99.60%
Imperatorin
AChE
BChE
98.72%
Rivastigmine
AChE
BChE
99.93%
Galanthamine
AChE
 99.96%
Garcinol
AChE
BChE
≥99.0%
α-NETA
AChE
 ≥98.0%
Scopoletin
AChE
 99.89%
Linarin
AChE
 98.00%
Physostigmine salicylate
AChE
 99.74%
Rivastigmine tartrate
AChE
 99.03%
Isoimperatorin
AChE
 99.61%
(-)-Huperzine A
AChE
 99.74%
Tacrine hydrochloride
AChE
BChE
99.95%
Sinapine
AChE
 99.96%
Timosaponin AIII
AChE
 99.73%
Chlorpyrifos
AChE
 99.94%
Epiberberine chloride
AChE
BChE
99.02%
Pyridostigmine bromide
AChE
 99.93%
Tacrine
AChE, IC50: 109 nM
 99.91%
Corydaline
AChE
 99.70%
Ethopropazine hydrochloride
AChE
BChE
99.66%
Jatrorrhizine chloride
AChE
 99.88%
Corynoline
AChE
 99.12%
(-)-Carvone
eel AChE, Ki: 2.19 mM
 99.91%
Nodakenin
AChE
 98.76%
Cyanidin-3-O-galactoside chloride
AChE
 99.20%
Itopride hydrochloride
AChE
 99.84%
Pralidoxime chloride
AChE
 99.73%
N-p-trans-Coumaroyltyramine
AChE
 98.78%
Coumaran
AChE
 99.54%
Galanthamine hydrobromide
AChE
 99.93%
Aaptamine
AChE, IC50: 0.23 μg/mL
BChE, IC50: 1.38 μg/mL
99.71%
Rhodiosin
AChE
 99.36%
Profenofos
AChE
 
Sinapine thiocyanate
AChE
 99.74%
Tacrine hydrochloride (hydrate)
AChE
BChE
99.98%
Acephate
AChE
 ≥98.0%
Physostigmine hemisulfate
AChE
 ≥99.0%
Rhodionin
AChE
 98.78%
Tenuifolin
AChE
 99.24%
(±)-Huperzine A
AChE
 98.73%
β-NETA
AChE
 ≥98.0%
Phenthoate
AChE
 98.71%
RPR121056
AChE
 99.59%
Phenserine
AChE
 99.55%
Jatrorrhizine hydroxide
AChE
 98.07%
Pralidoxime iodide
AChE
 ≥98.0%
Mca-YVADAP-Lys(Dnp)-OH TFA
AChE
 99.45%
Pteryxin 
BChE
99.96%
PCS1055 dihydrochloride
AChE
 98.88%
Manghaslin
AChE
 98.56%
Picfeltarraenin IA
AChE
 99.83%
Drofenine hydrochloride 
BChE
98.10%
Picfeltarraenin IB
AChE
 98.53%
Fenchlorphos
AChE
 99.87%
Ladostigil hydrochloride
AChE, IC50: 31.8 μM
 99.94%
Violanthin
AChE
 
Acotiamide monohydrochloride trihydrate
AChE
 99.79%
Benactyzine hydrochloride 
BChE, Ki: 0.01 mM
99.02%
Pirimiphos-methyl
AChE
 98.00%
Galanthaminone
AChE
 99.85%
BChE-IN-17
eel AChE, IC50: 686.4 μM
eqBCHE, IC50: 10.5 nM
hBCHE, IC50: 32.5 nM
99.07%
Neoeriocitrin
AChE
 99.93%
Zanapezil free base
AChE
 99.23%
Penconazole
AChE
 98.91%
PE154
AChE, IC50: 280 pM
BChE, IC50: 16 nM
99.01%
Zanapezil fumarate
AChE
 99.63%
Jatrorrhizine
AChE
 
Ebeiedinone
AChE
BChE
99.51%
P11149
AChE
 99.23%
Galanthamine N-Oxide
AChE
BChE
99.90%
Pitofenone hydrochloride
AChE
 99.88%
Epiberberine
AChE
BChE
98.46%
Pirimicarb
AChE
 99.50%
PCS1055
hAChE, IC50: 120 nM
 98.02%
Y13g dihydrochloride
AChE
 99.89%
Swertianolin
AChE
 99.54%
Zanapezil
AChE
 99.63%
Isoprocarb
AChE
 99.12%
Dihydrowithaferin A
AChE
 99.57%
Sophoflavescenol
AChE
BChE
98.78%
(±)-Marmesin
AChE
 
ASS234
AChE, IC50: 350 nM
BChE, IC50: 460 nM
99.6%
SD-6
hAChE, IC50: 0.907 μM
hBCHE, IC50: 1.579 μM
≥98.0%
Polygalacic acid
AChE
 98.92%
Territrem B
AChE
 
Isorosmanol
AChE
 99.40%
AChE/BChE-IN-10
AChE, IC50: 0.176 μM
BChE, IC50: 0.47 μM
99.67%
Anatoxin-a
AChE
 
Lucidadiol
AChE, IC50: 31.03 μM
BChE, IC50: 156.27 μM
≥98.0%
Z32439948 
BChE, IC50: 1.4 μM ([1])
HDAC6-IN-5
AChE, IC50: 0.72 μM
 
AChE/BChE-IN-1
AChE
BChE
ZLMT-12
AChE, IC50: 19.023 μM
BChE, IC50: 2.768 μM
AChE-IN-72
AChE, IC50: 0.59 μM
BChE, IC50: 5.02 μM
hAChE-IN-6
hAChE, IC50: 0.16 μM
hBCHE, IC50: 0.69 μM
SB-1436
EeAChE, IC50: 0.176 μM
EeAChE, Ki: 0.046 μM
eqBCHE, IC50: 0.37 μM
eqBCHE, Ki: 0.115 μM
hAChE-IN-9
hAChE, IC50: 0.05 μM
hBCHE, IC50: 2.85 μM
AChE-IN-14
AChE
 
AChE/BChE-IN-18
AChE, IC50: 0.315 μM
 
BChE-IN-6 
BChE, Ki: 0.182 μM
AChE-IN-81
AChE, IC50: 3.7 μM
AChE, Kd: 5.37 μM
 
Methylene Violet 3RAX
AChE, Ki: 1.58 μM
BChE, Ki: 0.51 μM
AChE-IN-60
AChE, IC50: 27 nM
BChE, IC50: 43 nM
Azamethiphos
AChE
 
AChE-IN-44
AChE
 
K203
AChE
 
AChE-IN-28
AChE, IC50: 0.2 nM
 
ChEs/MAOs-IN-2
AChE, IC50: 0.30 μM
BChE, IC50: 0.40 μM
Isogarcinol
AChE, IC50: 1.13 ± 0.0 μM
BChE, IC50: 8.30 ± 0.0 μM
BChE-IN-36
EeAChE, IC50: 72.1 nM
eqBCHE, IC50: 4.2 nM
Stemoninine
hAChE, IC50: 5.52 μM
 
AChE/BuChE-IN-5
AChE, IC50: 46.9 nM
RatBuChE, IC50: 3.5 nM
Dual AChE-MAO B-IN-1
AChE
 
Kuwanon U
AChE, IC50: 19.69 μM
AChE, IC50: 6.48 μM
BChE, Ki: 10.11 μM
BChE, Ki: 9.59 μM
AChE/BChE/MAO-B-IN-3
hAChE, IC50: 0.0473 μM
hBCHE, IC50: 0.0782 μM
hBChE-IN-2 
hBCHE, IC50: 0.67 μM
Y13g
AChE
 
AChE-IN-35
AChE, IC50: 5.88 μM
 
Z164597606 
eqBCHE, IC50: 1.3 μM
hBCHE, IC50: 1.7 μM
Pralidoxime
AChE
 
Xanthohumol I
AChE
BChE
SBN-284
EeAChE, IC50: 0.37 μM
hAChE, IC50: 0.31 μM
eqBCHE, IC50: 0.29 μM
MAO-IN-6
AChE, IC50: 4.48 μM
BChE, IC50: 17.03 μM
AChE/BACE1/GSK3β-IN-1
AChE, IC50: 1 μM
 
AChE/MAO-IN-1
hAChE, IC50: 0.0248 μM
 
Blestrin D 
BChE, IC50: 8.1 μM
AChE-IN-22
AChE
 
eeAChE-IN-2
AChE
 
AChE/BChE-IN-16
hAChE, IC50: 30 nM
hBCHE, IC50: 48 nM
hAChE/Aβ1-42-IN-1
AChE
 
Protriptyline
AChE, IC50: 0.06 mM
 
AChE/hCA I-IN-1
AChE, IC50: 302.2 nM
 
BChE-IN-19 
BChE, IC50: 0.04 μM
MAO-B-IN-7
hAChE, IC50: 41 nM
 
AChE/Aβ-IN-3
AChE, IC50: 1.29 μM
 
BuChE-IN-7 
hBCHE, IC50: 40 nM
eqBCHE, IC50: 80 nM
K027
AChE
BChE
hAChE/hBuChE/GSK-3β-IN-1
hAChE, IC50: 28.88 nM
hBCHE, IC50: 131.90 nM
AChE/BChE/MAO-B-IN-2
AChE, IC50: 83.9 nM
BChE, IC50: 31.2 nM
BuChE-IN-20 
BChE, IC50: 0.13 nM
Bis-(-)-8-demethylmaritidine
AChE
 
Carbonic anhydrase/AChE-IN-1
AChE, Ki: 5.07 nM
 
hAChE-IN-2
hAChE, IC50: 0.71 μM
 
BChE-IN-33 
BChE, IC50: 14.78 nM
BChE-IN-32 
hBCHE, IC50: 0.109 μM
AChE-IN-75
AChE
 
AChE/MAO-B-IN-3
hAChE, IC50: 0.0257 μM
 
Picfeltarraegenin X
AChE
 
MR33317
AChE, IC50: 41 nM
 
BChE-IN-16 
hBCHE, IC50: 3.8 nM
H3R antagonist 4
hAChE, IC50: 9.73 μM
EeAChE, IC50: 7.04 μM
eqBCHE, IC50: 13.40 ~ 88 μM
Multitarget AD inhibitor-2
AChE, IC50: 0.14 μM
BChE, IC50: 11.6 μM
hAChE/hBACE-1-IN-1
hAChE, IC50: 0.076 μM
hBACE-1, IC50: 0.23 μM
hBCHE, IC50: 1.204 μM
K1833
hAChE, IC50: 58 μM
hBCHE, IC50: 0.57 μM
AChE/CA I-IN-1
AChE, Ki: 1.85 μM
 
Desoxypeganine
AChE, IC50: 17 μM
BChE, IC50: 2 μM
BChE-IN-35 
BChE
AChE/BChE-IN-12
EeAChE, IC50: 2.57 ± 0.3 μM
eqBCHE, IC50: 3.26 ± 0.1 μM
Bisnorcymserine 
BChE, IC50: 0.228 nM
BChE-IN-12 
BChE, IC50: 2.3 μM
hCA I-IN-4
AChE, Ki: 21.21 nM
BChE, Ki: 7.65 nM
hAChE/hBACE-1-IN-4
hAChE, IC50: 0.283 μM
hBCHE, IC50: 0.231 μM
AChE-IN-19
AChE
 
AChE-IN-77
AChE, IC50: 29.46 μM
 
Lycodoline 
BChE, IC50: 667 μM
KBR 2822
AChE
 
AChE-IN-8
AChE
 
CUR-IPA
hAChE, IC50: 59.30 μM
hBCHE, IC50: 60.66 μM
AChE/BChE-IN-25
hAChE, IC50: 7.9 nM
eqBCHE, IC50: 0.79 nM
AChE-IN-46
AChE
 
Dual AChE-MAO B-IN-3
EeAChE, IC50: 0.58 ± 0.0 μM
 
BuChE-IN-12 
BChE, IC50: 0.52 nM
Broussonin A 
BChE, IC50: 4.16 μM
Memoquin
hAChE, IC50: 1.55 nM
 
S21-1011 
eqBCHE, IC50: 0.059 μM
hBCHE, IC50: 0.162 μM
AChE-IN-17
AChE
 
CEase-IN-1
AChE, IC50: 45.9 μM
 
AChE-IN-5
AChE
 
ChE/Aβ1-42-IN-1
AChE
 
AChE/BChE-IN-11
AChE, IC50: 70 μM
BChE, IC50: 71 μM
AChE/BuChE-IN-1
AChE
 
Eseramine
AChE, IC50: 9300 nM
 
AChE/BChE-IN-17
AChE, IC50: 125.06 ± 2 nM
BChE, IC50: 119.68 ± 2 nM
AChE/BChE-IN-23
hAChE, IC50: 0.91 μM
eqBCHE, IC50: 1.19 μM
hBCHE, IC50: 1.02 μM
AChE-IN-69
AChE, IC50: 1.67 μM
 
BChE-IN-39
AChE, IC50: 3.98 μM
BChE, IC50: 0.08 μM
Kokusaginine
AChE, IC50: 28.2 μM
 
BChE-IN-31
AChE, IC50: 5.9 μM
BChE, IC50: 65 nM
AChE/BChE-IN-20
AChE, IC50: 34.81 μM
BChE, IC50: 20.66 μM
NDs-IN-1
hAChE
hBCHE
AChE/BChE/MAO-B-IN-5
AChE, IC50: 0.24 μM
BChE, IC50: 6.29 μM
BuChE-IN-16 
BChE, IC50: 0.33 μM
BChE-IN-5
AChE
BChE
Flucopride
AChE, IC50: 24 nM
 
hAChE-IN-10
hAChE, IC50: 6.34 nM
 
AChE-IN-85
AChE, IC50: 0.083 μM
 
tau/Aβ40 aggregation-IN-1
hAChE, IC50: 16.10 μM
equine serum BChE, IC50: 0.96 μM
AChE/BChE-IN-6
hAChE, IC50: 2.248 μM
hBCHE, IC50: 0.809 μM
AChE-IN-24
AChE
 
AChE-IN-51
AChE, IC50: 84 nM
BChE, IC50: 97 nM
Artanin
AChE, IC50: 51 μM
 
AChE/BuChE/MAO-B-IN-1
hAChE, IC50: 4.8 μM
hBCHE, IC50: 13.7 μM
CL-13 
BChE, IC50: 1.15 μM
Monarsen
AChE
 
AChE-IN-12
AChE
 
AChE/BuChE-IN-3
AChE, IC50: 0.65 μM
BChE, IC50: 5.77 μM
AChE/BChE-IN-24
AChE, IC50: 16.38 μM
BChE, IC50: 10.44 μM
hAChE-IN-8
hAChE, IC50: 0.486 μM
hBCHE, IC50: 0.542 μM
AChE-IN-64
AChE, IC50: 36.9 μM
 
eeAChE-IN-3
EeAChE, IC50: 0.54 μM
RatAChE, IC50: 0.49 μM
RatBuChE, IC50: 8.54 μM
BChE-IN-26
AChE, Ki: 35 μM
BChE, Ki: 1.6 μM
α-Glucosidase-IN-68
AChE, IC50: 0.774 μM
BChE, IC50: 0.793 μM
TRV-7019 
BChE
99.64%
AChE-IN-21
EeAChE, IC50: 2.66 nM
RatBuChE, IC50: 19.10 μM
AChE-IN-67
AChE, IC50: 0.033±0.00 μM
BChE, IC50: >100 μM
AChE/BChE-IN-26 
eqBCHE, IC50: 4.11 μM
AChE/BuChE-IN-6
AChE, IC50: 1.24 μg/mL
BChE, IC50: 1.85 μg/mL
MAO-A/B-IN-3
AChE, IC50: 1370 nM
 
AChE-IN-52
AChE
 
BChE-IN-15
hAChE, IC50: 558.6 nM
hBCHE, IC50: 1.76 nM
AChE-IN-59
AChE, IC50: 0.05 μM
BChE, IC50: 4.68 μM
Desoxypeganine hydrochloride
AChE, IC50: 17 μM
BChE, IC50: 2 μM
AChE/BChE-IN-3 hydrochloride
AChE
BChE
MR2938
AChE, IC50: 5.04 ± 0.7 μM
BChE, IC50: >20 μM
Pitofenone
AChE
 
BChE-IN-10 
BChE, IC50: 6.4 μM
AChE/MAO-B-IN-4
AChE
 
hCAI/II-IN-8
AChE, IC50: 46.27 ±0.7 nM
BChE, IC50: 43.38 ± 0. nM
Itopride
AChE
 
S16–1029 
eqBCHE, IC50: 11.35 nM
hBCHE, IC50: 48.1 nM
BChE-IN-11 
BChE, IC50: 2.1 ± 0.3 μM
Isoprocarb-d3
AChE
 
AChE/BuChE/MAO-B-IN-2
AChE, IC50: 5.3 μM
BChE, IC50: 12.4 μM
MHP 133
AChE, Ki: 69 μM
 
hBChE-IN-3
AChE, IC50: 7.4 nM
BChE, IC50: 1.9 nM
AChE/MAO-IN-2
AChE, IC50: 0.0224 μM
 
hAChE-IN-3
AChE, IC50: 0.44 μM
BChE, IC50: 0.08 μM
AChE/PDE4-IN-1
AChE, IC50: 0.28 μM
 
α-Amylase/α-Glucosidase-IN-7
AChE, IC50: 9.25 μM
BChE, IC50: 10.06 μM
hAChE-IN-1
hAChE, IC50: 1.09 μM
 
AChE-IN-63
hAChE, IC50: 0.103 μM
hBCHE, IC50: 10 μM
BChE-IN-34 
eqBCHE, IC50: 25 nM
AChE-IN-4
AChE, IC50: 24.1 μM
 
BChE-IN-22 
eqBCHE, IC50: 0.53 μM
BuChE-IN-11 
hBCHE, IC50: 0.44 μM
AChE-IN-20
AChE, IC50: 397.32 nM
AChE, Ki: 335.76 nM
 
BChE-IN-28
AChE, IC50: 3691 nM
BChE, IC50: 8 nM
BChE, Ki: 12.16 nM
AChE-IN-34
AChE, IC50: 3.98 μM
AChE, Ki: 0.044 μM
 
Dual AChE-MAO B-IN-4
AChE, IC50: 261 nM
 
Manumycin B
AChE, IC50: 15 mM
 
(Rac)-Sclerone
AChE, IC50: 192.65 ± 1 μg/mL
 
BChE/MAO-B-IN-1 
BChE, IC50: 375 nM
AChE-IN-82
EeAChE, IC50: 0.072 μM
eqBCHE, IC50: 9.81 μM
AChE-IN-68
hAChE, IC50: 0.040 ± 0. μM
hBCHE, IC50: >1000 μM
eeAChE-IN-1
AChE
 
AChE/BChE-IN-19
AChE, IC50: 21.45 nM
BChE, IC50: 18.42 nM
AChE-IN-55
EeAChE, IC50: 4.8 μM
 
Methyl ganoderate A acetonide
AChE
 
Isograndifoliol
AChE, IC50: 342.9 μM
BChE, IC50: 0.9 μM
hBChE-IN-1
EeAChE, IC50: 0.18 μM
hAChE, IC50: 7.84 ± 0.8 μM
hBCHE, IC50: 0.0070 ± 0 μM
equine serum BChE, IC50: 0.088 μM
AChE/Aβ-IN-4
AChE, IC50: 1.72 ± 0.1 μM
 
AChE-IN-47
AChE
 
AChE-IN-11
AChE
 
AChE-IN-10
AChE
 
Velnacrine
AChE, IC50: 3.27 μM
 
BChE-IN-38
AChE, Ki: 14.09 nM
BChE, Ki: 1.15 nM
AChE-IN-56
AChE
 
hAChE/hBACE-1-IN-2
hAChE, IC50: 0.113 μM
hBACE-1, IC50: 0.38 μM
hBCHE, IC50: 1.48 μM
BChE-IN-29
AChE, IC50: 0.74 μM
BChE, IC50: 0.075 μM
Benactyzine 
BChE, Ki: 0.01 mM
Donepezil N-oxide
AChE
 
WAY-361789
AChE
 
Buxbodine B
AChE, IC50: 50 μM
 
1,2-Didehydrotanshinone IIA 
BChE, IC50: 5.98 μM
AL284
AChE
 
T14-A24
AChE, Ki: 22 nM
 
7-Methoxytacrine
hAChE, IC50: 10.5 μM
hBCHE, IC50: 21 μM
TAE-1
AChE